Endocrine Abstracts

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

Introduction: Hyperglycemia in type 1 diabetes mellitus (T1DM) is an important determinant of bone health. However, data on the effect of glycemic changes on bone metabolism are limited. The aim of this study was to evaluate BMD in patients with T1DM in relation to changes of glycemic control.Methods/Design: We studied 118 uncomplicated patients with T1DM (GroupD) (mean age: 30.12+8.78years, F/M: 65/53) and 94 healthy controls (GroupC) matched for age, s...

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), pho...

Introduction: Type 2 diabetes mellitus (T2DM) affects bone metabolism, but its relation with bone mineral density (BMD) remains controversial. It is also known that T2DM is associated with hypogonadism in males. Male hypogonadism can also affect BMD. Thus the aim of this study was to evaluate BMD in male patients with T2DM with and without hypogonadism.Methods/design: Hypogonadism was defined as serum free Testosterone (fT) value <5 ng/dl or 5–9...

Graves’ orbitopathy (GO) is an auto-immune disorder that targets intra-orbital tissues. It is well proven to involve inflammatory hypertrophy of the rectus EOMs. Superior oblique (SO) muscle has been sporadically reported to be involved in GO. However, there are extremely few reports in the literature that refer to the involvement of the inferior oblique (IO) muscle and here we present such a case.A 33-year-old man with unilateral exophthalmos was r...

Background: Clinical evaluation of Graves’ orbitopathy (GO) is often insufficient. Frequently it is difficult to decide whether a case of GO is active, or to detect the degree of severity. STIR sequence MRI suppresses signal from fat and thus in the orbits can also detect active inflammation and oedema of extra-ocular muscles (EOMs). The aim of the present study is to examine whether imaging of rectus EOMs with STIR MRI could provide additional information for the activit...

Introduction: Limited data, support the notion that testosterone induces oxidative stress. Corticotropin-releasing hormone (CRH) participates locally in the endothelial inflammatory response by regulating the pro-oxidative mechanisms of the endothelium, inducing its adaptation to local stress. The present study was undertaken to determine whether the CRH induced pro-oxidant activity in macroendothelial cells under basal conditions, is regulated In vitro by androgen (t...

Introduction: Limited data exist on testosterone and oxidative stress induction. The present study was undertaken to evaluate, in vitro, the role of physiological concentrations of androgens (testosterone-DHT) in modulating the pro-oxidant and antioxidant activity of intact endothelial cells.Materials and methods: EA.hy926 macroendothelial cells were cultured in DMEM phenol red free without FBS for 24 hours. Growth medium was replaced and then testostero...

Introduction: Existing data suggest that Type 1 Diabetes Mellitus (T1DM) can affect both hypothalamic-pituitary-testis axis and bone health. The mechanisms by which sex steroids influence bone remodeling remain incompletely understood. Data linking gonadal function and bone turnover in male patients with T1DM are lacking. The purpose of this study was to examine any possible association between sex steroids levels and parameters of bone assessment in male adult patients with T...

Introduction: Type 1 diabetes mellitus (T1DM) is associated with reduced bone mineral density (BMD) and increased bone turnover. However, data regarding the influence of glycemic control on bone are limited. The aim of this study was to evaluate BMD and bone remodeling markers in patients with T1DM in relation to changes in glycemic control.Methods/design: We studied 107 patients with T1DM (Group-D) (mean age: 34+8.1 years, M/F: 48/59) and 95 healthy con...